SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

SCHEDULE 13D

INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT

TO § 240.13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2(a)

(Amendment No.     )*

Valeritas Holdings, Inc.

(Name of Issuer)

Common Stock, par value $0.001

(Title of Class of Securities)

91914N 202

(CUSIP Number)

Andrei Dorenbaum

Capital Royalty L.P.

1000 Main St. Suite 2500

Houston, TX 77002

(713) 209-7350

(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)

March 28, 2017

(Date of Event Which Requires Filing of This Statement)

If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of Rule 13d-1(e), Rule 13d-1(f) or Rule 13d-1(g), check the following box  ☐.

Note. Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See §240.13d-7 for other parties to whom copies are to be sent.

The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes.)

Item 1. Security and Issuer

This statement relates to the common stock, par value $0.001 per share (the “Shares”), of Valeritas Holdings, Inc., a Delaware corporation (the “Issuer”), with principal executive offices at 750 Route 202 South, Suite 600, Bridgewater, NJ 08807.

Item 2. Identity and Background

(a) The Shares reported herein are held by certain funds (the “Funds”) for which Capital Royalty L.P., a Delaware limited partnership (“Capital Royalty”), serves as the investment manager. The Funds are the following: (i) Capital Royalty Partners II L.P., a Delaware limited partnership; (ii) Capital Royalty Partners II (Cayman) L.P., a Cayman Islands exempted limited partnership; (iii) Capital Royalty Partners II Parallel Fund “A” L.P., a Delaware limited partnership; (iv) Capital Royalty Partners II Parallel Fund “B” (Cayman) L.P., a Cayman Islands exempted limited partnership; and (v) Parallel Investment Opportunities Partners II, L.P., a Delaware limited partnership

Capital Royalty and the Funds are each referred to herein individually as a “Reporting Person” and collectively as the “Reporting Persons.”

(b) The principal business address of Capital Royalty and the Funds is1000 Main St. Suite 2500 Houston, TX 77002.

(c) The principal business of Capital Royalty and the Funds is healthcare-focused investments.

(d) Neither Capital Royalty nor the Funds has, during the last five years, been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors).

(e) Neither Capital Royalty nor the Funds has, during the last five years, been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.

(f) With respect to the citizenship of each Reporting Person, see Item 6 on the cover pages hereto.

Item 3. Source and Amount of Funds or Other Consideration

The Shares purchased in the Issuer’s initial public offering were acquired at an aggregate purchase amount of $40,000,000.00 with working capital of the Funds. The Series A Convertible Preferred Stock was acquired pursuant to a Series A Preferred Stock Purchase Agreement entered into on March 22, 2017 by and among the Issuer, the Funds and WCAS Capital Partners IV, L.P. (the “Purchase Agreement”), which provided for the conversion of an aggregate $27.5 million of outstanding principal amount of the Issuer’s debt into an aggregate amount of 2,750,000 Series A Convertible Preferred Stock. Under the Purchase Agreement, $25.0 million of the Issuer’s debt held by the Funds was converted into 2,500,000 shares of Series A Convertible Preferred Stock.

In connection with the Issuer’s private placement financing in September 2015, 14,393,596 shares of Series AB Preferred Stock were issued to the Funds. During February, March and April of 2016, the Funds exercised warrants with respect to 5,900,000 Series AB Preferred Stock for aggregate consideration of $7,375,000. Immediately prior to the Issuer’s 2016 reverse merger transaction, all outstanding shares of Series AB Preferred Stock were converted to common stock at conversion rate of 0.02982. All outstanding warrants that were not exercised were cancelled immediately prior to such reverse merger transaction.

Item 4. Purpose of Transaction

The Reporting Persons have acquired beneficial ownership of the Shares for investment purposes, and such acquisition has been made in the Reporting Persons’ ordinary course of business.

In pursuing such investment purposes, the Reporting Persons may further purchase, hold, vote, trade, dispose of or otherwise deal in the Shares at such times, and in such manner, as they deem advisable to benefit from changes in the market prices of such Shares, changes in the Issuer’s operations, business strategy or prospects, or from a sale or merger of the Issuer or otherwise. To evaluate such alternatives, the Reporting Persons will routinely monitor the Issuer’s operations, prospects, business development, management, competitive and strategic matters, capital structure, and prevailing market conditions, as well as alternative investment opportunities, liquidity objectives and other investment considerations. Furthermore, the Reporting Persons may from time to time discuss various matters with management and directors of the Issuer, other shareholders, industry analysts, existing or potential strategic partners or competitors, investment and financing professionals, sources of credit and other investors.

The Reporting Persons have no current intention to propose changes in the Issuer’s operations, governance or capitalization, or to propose one or more of the other actions described in subsections (a) through (j) of Item 4 of Schedule 13D. However, the Reporting Persons reserve the right to formulate other plans and/or make other proposals, and take such actions with respect to his investment in the Issuer, including any or all of the actions set forth in paragraphs (a) through (j) of Item 4 of Schedule 13D, or to acquire additional Shares or dispose of all the Shares beneficially owned, in the public market, in privately negotiated transactions (which may be with the Issuer or with third parties) or otherwise. The Reporting Persons may at any time reconsider and change their plans or proposals relating to the foregoing.

Item 5. Interest in Securities of the Issuer

The percentages of Shares owned the Reporting Persons are based upon 9,639,585 Shares outstanding, which includes 6,889,585 shares of common stock and 2,750,000 shares of Series A Convertible Preferred Stock outstanding immediately after the Issuer’s initial public offering, as reported in the Issuer’s Prospectus filed on March 24, 2017 (Registration No. 333-215897).

Item 6. Contracts, Arrangements, Understandings or Relationships with Respect to Securities of the Issuer

Lock-Up Agreement

In connection with the Issuer’s initial public offering, the Reporting Persons entered into a lock-up agreement that, subject to limited exceptions, prohibits the Reporting Persons from offering for sale, pledging, selling, contracting to sell, selling any option or contract to purchase, purchasing any option or contract to sell, granting any option, right or warrant to purchase, lending, or otherwise transferring or disposing of, directly or indirectly, any Shares or any securities convertible into or exercisable or exchangeable for Shares; or entering into any swap or other arrangement that transfers to another, in whole or in part, any of the economic consequences of ownership of the Shares, for a period of 180 days following March 22, 2017.

The description of the above agreement does not purport to be a complete description and is qualified in its entirety by reference to the full text of such agreement, which is filed as part of this Schedule 13D and incorporated by reference herein.

Term Loan

On May 23, 2013, the Issuer and certain Reporting Persons entered into a term loan agreement (the “Term Loan”) of $50.0 million structured as a senior secured loan with a six-year term. The Term Loan is secured by substantially all of the Issuer’s assets, including its material intellectual property. The Term Loan bears interest at 11% per annum and compounds annually.

On February 9, 2017, the Term Loan was amended in order to (i) extend the interest only-period of the Term Loan by one year to March 31, 2022 from March 31, 2021; (ii) extend the time required prior to the initial required cash interest payments by one year to June 30, 2019 from June 30, 2018; (iii) extend the deadline for full payment under the Term Loan to March 31, 2022 from March 31, 2021; and (iv) reduce the minimum cash and cash equivalent requirements to $2.0 million from the previous requirement of $5.0 million.

Pursuant to the Purchase Agreement, the Issuer and the Funds agreed to convert $25 million of the outstanding principal amount of the Issuer’s debt held by the Funds, including the Term Loan, into 2,500,000 shares of the Issuer’s to-be designated Series A Convertible Preferred Stock. Upon completion of the Issuer’s initial public offering, each share of Series A Convertible Preferred Stock became convertible into one share of the Issuer’s common stock.

Contemporaneously with the execution of the Purchase Agreement, the Issuer, the Funds and WCAS Capital Partners IV, L.P. also entered into a Registration Rights Agreement (the “Registration Rights Agreement”) pursuant to which the Issuer agreed, at the election of the holders of a majority of the Registrable Securities (as

defined in the Registration Right Agreement) then outstanding at any time at least 90 days after the closing of the conversion, to file a registration statement with the SEC within 90 days after the initial request to register 100% of the number of Shares issuable upon conversion of the Series A Convertible Preferred Stock.

The descriptions of the above agreements do not purport to be complete descriptions and are qualified in their entirety by reference to the full text of such agreements, which are filed as part of this Schedule 13D and incorporated by reference herein.

Voting Agreement

On January 29, 2016, the Issuer, the Funds and the other parties thereto entered into a Third Amended and Restated Voting Agreement (the “Voting Agreement”), pursuant to which the parties thereto agreed, among other things, to vote their Shares as may be necessary to elect three directors to the board of directors of the Issuer designated by Capital Royalty Partners II L.P. or its Affiliates (as defined in the Voting Agreement) for so long as such persons continue to beneficially own any Shares. Luke Düster, who is a managing director at Capital Royalty, has served as a member of the Issuer’s board of directors since January 2016 pursuant to the Voting Agreement.

The Voting Agreement also provides for certain transfer restrictions as well as drag-along and tag-along rights with respect to the Shares.

The description of the Voting Agreement does not purport to be a complete description and is qualified in its entirety by reference to the full text of such agreement, which is filed as part of this Schedule 13D and incorporated by reference herein.

Item 7. Material to be Filed as Exhibits

SIGNATURE

After reasonable inquiry and to the best of his knowledge and belief, each of the undersigned certifies that the information set forth in this statement is true, complete and correct.

Dated: April 7, 2017

EXHIBIT INDEX

Exhibit A

TRANSACTIONS DURING PAST 60 DAYS

The Reporting Persons engaged in the following transactions in shares of common stock of the Issuer during the past 60 days:

Exhibit B

JOINT FILING AGREEMENT

In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, the persons named below agree to the joint filing on behalf of each of them of a statement on Schedule 13D (including amendments thereto) with respect to the common stock, par value $0.001 per share, of Valeritas Holdings, Inc., and further agree that this Joint Filing Agreement be included as an Exhibit to such joint filing. In evidence thereof, the undersigned hereby execute this Joint Filing Agreement.

Dated: April 7, 2017

Exhibit I

VALERITAS, INC.

THIRD AMENDED AND RESTATED VOTING AGREEMENT

This Third Amended and Restated Voting Agreement (the “Agreement”) is made and entered into as of January 29, 2016, by and among (i) Valeritas, Inc., a Delaware corporation (the “Company”), (ii) the holders of the Company’s issued and outstanding shares of Series AB Preferred Stock of the Corporation, par value $0.00001 per share (“Series AB Preferred Stock”), Series AA Preferred Stock of the Corporation, par value $0.00001 per share (“Series AA Preferred Stock”), Series D Preferred Stock of the Corporation, par value $0.00001 per share (“Series D Preferred Stock”, and together with Series AB Preferred Stock and Series AA Preferred Stock, “Preferred Stock”) and Common Stock of the Corporation, par value $0.00001 (“Common Stock”) listed on Schedule A attached hereto (collectively, the “Investors”), and (iii) the holders of the Company’s issued and outstanding shares of Common Stock and holders of options to acquire the Company’s Common Stock listed on Schedule B attached hereto or who hereafter become party to this Agreement (collectively, the “Other Stockholders” and together with the Investors, the “Stockholders”). The Company, the Investors and the Other Stockholders are individually referred to herein as a “Party” and are collectively referred to herein as the “Parties.” The Company’s Board of Directors is referred to herein as the “Board.” Certain other capitalized terms used in this Agreement but not defined where first used in this Agreement are defined in Section 24 of this Agreement.

WITNESSETH:

WHEREAS, effective as of June 19, 2014, the Company restructured its capitalization through the merger of a wholly-owned subsidiary of Valeritas Holdings, LLC (“Holdings”) into the Company pursuant to the Agreement and Plan of Merger and Reorganization, dated June 9, 2014 (the “Merger”). As a result of the Merger, immediately following the effective time of the Merger, the Company became a wholly owned subsidiary of Holdings and the former holders of capital stock of the Company outstanding as of the effective time of the Merger became holders of Holdings membership interests;

WHEREAS, concurrently with the execution of this Agreement, the Corporation and certain of the Investors are parties to the Series AB Preferred Stock Purchase Agreement, dated as of September 28, 2015, as amended (the “Purchase Agreement”), pursuant to which such Investors have agreed to purchase shares of Series AB Preferred Stock;

WHEREAS, also concurrently with the execution of this Agreement, the Company’s Certificate of Incorporation then in effect was amended and restated under the Eighth Amended and Restated Certificate of Incorporation (the “Restated Certificate”), which provides that holders of shares of Common Stock and holders of shares of Preferred Stock, voting together as a single class on an as converted to Common Stock basis, shall be entitled to elect the members of the Board;

WHEREAS, the obligations in the Purchase Agreement are conditioned upon the execution and delivery of this Agreement; and

WHEREAS, the Company, the Investors and the Other Stockholders desire to have their respective voting rights and certain other rights and restrictions governed by this Agreement.

NOW, THEREFORE, in consideration of the foregoing premises and certain other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties agree as follows:

1. Agreement to Vote. Each Investor, as a holder of shares of Preferred Stock or Common Stock, hereby agrees on behalf of itself and any transferee or assignee of any such shares of Preferred Stock or Common Stock, to hold all of the shares of Preferred Stock and Common Stock registered in its name (and any securities of the Company issued with respect to, upon conversion of, or in exchange or substitution of such Preferred Stock, and any other voting securities of the Company subsequently acquired by such Investor) (the “Investor Shares”) subject to, and to vote the Investor Shares at a regular or special meeting of stockholders (or by written consent) in accordance with, the provisions of this Agreement. Each Other Stockholder hereby agrees on behalf of itself and any transferee or assignee to hold all of the shares of Common Stock and any other securities of the Company acquired by such Other Stockholder, in the future (and any securities of the Company issued with respect to, upon conversion of, or in exchange or substitution for such securities) (the “Other Shares”) subject to, and to vote the Other Shares, if such securities are entitled to vote, at a regular or special meeting of stockholders (or by written consent) in accordance with, the provisions of this Agreement.

2. Board Size. The holders of Investor Shares and Other Shares shall vote, or cause to be voted, at a regular or special meeting of stockholders (or by written consent) such shares that they own (or as to which they have voting power) to set the size of the Board at up to seven (7) but not less than five (5) directors; provided, however, that such Board size may be set at any time within this range by the Board and subsequently increased or decreased by means of an amendment of this Agreement in accordance with Section 16 hereof.

3. Election of Directors; Chairman of the Board.

(a) In any election of directors of the Company, the Investors and Other Stockholders holding securities of the Company entitled to vote thereon, voting together as a single class on an as converted to Common Stock basis, shall each vote, or cause to be voted, at any regular or special meeting of stockholders (or by written consent), such number of voting securities of the Company then owned by them (or as to which they then have voting power) as may be necessary to elect:

(i) three (3) directors designated by Capital Royalty Partners II L.P. or its Affiliates for so long as such Persons and their Affiliates continue to own beneficially any shares of Common Stock of the Company (including shares of Common Stock issued or issuable upon conversion of Preferred Stock) (each, a “Capital Royalty Director”);

(ii) one (1) director who is the Company’s Chief Executive Officer, who shall initially be Kristine Peterson (the “CEO Director”), provided that if for any reason the CEO Director shall cease to serve as the Chief Executive Officer of the Company, the Investors and Other Stockholders shall promptly vote their respective voting securities (i) to remove the former Chief Executive Officer from the Board if such person has not resigned as a member of the Board and (ii) to elect such person’s replacement as Chief Executive Officer of the Company as the new CEO Director; and

(iii) one (1) independent director not otherwise an Affiliate of the Company or Capital Royalty Partners II L.P., who is mutually acceptable to Capital Royalty Partners II L.P. and the CEO Director.

(b) The Board may, at any time, appoint up to two (2) independent directors, who are industry experts and not employed by the Company and not affiliated with any holder of Preferred Stock, upon the consent of a majority of the Board.

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To the extent that any of clauses (a)(i) through (iii) or (b) above shall not be applicable, any member of the Board who would otherwise have been designated in accordance with the terms thereof shall instead be voted upon by all the stockholders of the Company entitled to vote thereon in accordance with, and pursuant to, the Company’s Restated Certificate.

4. Removal.

(a) Each Stockholder also agrees to vote, or cause to be voted, all Investor Shares and Other Shares owned by such Stockholder, as applicable, or over which such Stockholder has voting control, from time to time and at all times, in whatever manner as shall be necessary to ensure that:

(i) no director elected pursuant to Section 3 may be removed from office unless (i) such removal is directed or approved by the affirmative vote or consent of the Person entitled to designate that director; or (ii) the Person(s) entitled to designate or approve such director is no longer so entitled to designate or approve such director;

(ii) subject to Section 4(b), any vacancies created by the resignation, removal or death of a director elected pursuant to Section 3 shall be filled pursuant to the provisions of Section 3; and

(iii) upon the request of any party entitled to designate a director as provided in Section 3 to remove such director, such director shall be removed.

(b) Notwithstanding anything in this Agreement to the contrary, in the event that an Investor that has the right to designate a member of the Board pursuant to Section 3 hereof becomes subject to the Special Mandatory Conversion (as defined in the Restated Certificate) pursuant to Section 3B of Article IV.B. of the Restated Certificate, then (i) upon such Special Mandatory Conversion, such Investor’s right to designate a member of the Board shall immediately terminate, and (ii) as soon as reasonably practicable after such conversion, each Stockholder hereby agrees to vote, or cause to be voted, all Investor Shares and Other Shares owned by such Stockholder or over which such Stockholder has voting control, in whatever manner as shall be necessary to remove the designee of such Investor from the Board. Notwithstanding anything to the contrary set forth in Section 4(a)(ii), any vacancies created by the removal of a director pursuant to this Section 4(b) shall be filled by individuals designated by the holders of a majority of the then outstanding shares of Preferred Stock, voting together as a single class, and each Stockholder hereby agrees to vote, or cause to be voted, all Investor Shares and Other Shares owned by such Stockholder or over which such Stockholder has voting control, in whatever manner as shall be necessary to elect such designees to the Board.

5. Transfers; Drag-Along Right; Tag-Along Right.

(a) Transfers. Each Stockholder agrees that it shall not transfer any shares of capital stock of the Company owned by it except as expressly provided in Sections 5(b), (c) and (d). Any transfer or attempted transfer of any such shares in violation of any provision of this Agreement shall be void ab initio, and the Company shall not record any such transfer on its books or treat any purported transferee of such shares as the owner of such shares for any purpose.

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(b) Drag-Along Right. In the event that (i) the Board and (ii) the holders of at least a majority of the then outstanding shares of Preferred Stock, voting together as a single class on an as converted to Common Stock basis, approve a Sale of the Company (as defined below), then each Stockholder hereby agrees with respect to all securities of the Company which it own(s) or otherwise exercises voting or dispositive authority:

(i) in the event such transaction is to be brought to a vote at a stockholder meeting, after receiving proper notice of any meeting of stockholders of the Company to vote on the approval of such Sale of the Company, to be present, in person or by proxy, as a holder of shares of voting securities, at all such meetings and be counted for the purposes of determining the presence of a quorum at such meetings;

(ii) to vote or cause to be voted (in person, by proxy or by action by written consent, as applicable) all shares of the capital stock of the Company as to which it has beneficial ownership in favor of such Sale of the Company and in opposition of any and all other proposals that could reasonably be expected to delay or impair the ability of the Company to consummate such Sale of the Company;

(iii) to refrain from exercising any dissenters’ rights or rights of appraisal under applicable law at any time with respect to such Sale of the Company;

(iv) to execute and deliver all related documentation and take such other action in support of or to consummate such Sale of the Company as shall reasonably be requested by the Company; and

(v) except for this Agreement, no Stockholder, or any Affiliate thereof, shall deposit any shares of capital stock beneficially owned by such Stockholder, or an Affiliate thereof, in a voting trust or subject any such shares of capital stock to any arrangement or agreement with respect to the voting of such shares of capital stock.

Notwithstanding the foregoing, no Investor shall be required to vote in the manner described by this Section 5(b) unless (i) the net proceeds of such Sale of the Company are to be distributed to stockholders of the Company in accordance with Section 2 of Article IV(B) of the Restated Certificate, (ii) any representation or warranty required to be made by any Investor in connection with such Sale of the Company shall be limited to customary representations and warranties relating to such Investor and shares of capital stock of the Company owned by such Investor, (iii) the liability for indemnification, if any, of each Stockholder in the Sale of the Company for the inaccuracy of any representation or warranty made by the Company or applicable Stockholders in connection with such Sale of the Company, is several and not joint with any other person or entity (although nothing set forth herein shall be deemed to mean that an escrow fund established from the proceeds of a Sale of the Company for indemnification of such inaccuracy shall be a violation of the foregoing), is pro rata in proportion to the amount of consideration paid to such Stockholder in connection with such Sale of the Company and does not exceed the maximum amount of consideration to be received by such Stockholder from the Sale of the Company and (iv) if a choice with regards to the form of consideration is given to any Investor then all Investors shall be given the same choice.

(c) Tag-Along Rights. Except as provided in Section 5(d), each Investor may transfer shares of capital stock of the Company owned by it, provided that as a condition of such Proposed Transfer such Investor grants to each other Party a Tag-Along Right with respect to such Proposed Transfer, in which case, the following terms and conditions shall apply:

(i) Notice. The Investor proposing to make a Proposed Transfer (the “Transferring Holder”) must deliver a Proposed Transfer Notice to each other Party not later than thirty (30) days prior to the consummation of such Proposed Transfer.

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(ii) Exercise of Right. Each respective Party (except for the Transferring Holder) may elect to exercise its Tag-Along Right and participate on a pro rata basis (as described in subsection 5(d)(iii)) in such Proposed Transfer on the same terms and conditions specified in the Proposed Transfer Notice. Each Party who desires to exercise its Tag-Along Right (each, a “Participating Investor”) must give the Transferring Holder written notice to that effect within fifteen (15) days after delivery of the Proposed Transfer Notice, and upon giving such notice such Participating Investor shall be deemed to have effectively exercised its Tag-Along Right.

(iii) Shares Includable. Each Participating Investor may include in the Proposed Transfer all or any part of such Participating Investor’s Investor Shares or Other Shares equal to the product obtained by multiplying (i) the aggregate number of shares of Transfer Stock subject to the Proposed Transfer by (ii) a fraction, the numerator of which is the number of Investor Shares (on an as-converted to Common Stock basis) and Other Shares owned by such Participating Investor immediately before consummation of the Proposed Transfer and the denominator of which is the total number of Investor Shares (on an as-converted to Common Stock basis) and Other Shares outstanding immediately prior to the consummation of the Proposed Transfer.

(iv) Purchase and Sale Agreement. The Participating Investors and the Transferring Holder agree that the terms and conditions of any Proposed Transfer will be memorialized in, and governed by, a written purchase and sale agreement with the Prospective Transferee (the “Purchase and Sale Agreement”) with customary terms and provisions for such a transaction, and the Participating Investors and the Transferring Holder further covenant and agree to enter into such Purchase and Sale Agreement as a condition precedent to any sale or other transfer in accordance with this Section 5(c). The Purchase and Sale Agreement shall provide that the liability for indemnification by any Prospective Transferee shall not exceed the consideration received by such Prospective Transferee pursuant to the Purchase and Sale Agreement.

(v) Allocation of Consideration. The aggregate consideration payable to the Participating Investors and the Transferring Holder shall be allocated based on the number of shares of Transfer Stock sold to the Prospective Transferee by each Participating Investor and the Transferring Holder as provided in paragraph (iii) and shall be allocated to the Participating Investors and the Transferring Holder in accordance with Section 2 of Article IV(B) of the Restated Certificate as if such transfer were a Liquidation Event (as defined in the Restated Certificate).

(vi) Purchase by Selling Stockholder; Deliveries. Notwithstanding paragraph (iv) above, if any Prospective Transferee or Transferees refuse(s) to purchase securities subject to the Tag-Along Right from any Participating Investor or upon the failure to negotiate in good faith a Purchase and Sale Agreement reasonably satisfactory to the Participating Investors, the Transferring Holder and any Party may not sell any Transfer Stock to such Prospective Transferee or Transferees unless and until, simultaneously with such sale, the Transferring Holder purchases all securities subject to the Tag-Along Right from such Participating Investor or Investors on the same terms and conditions (including the proposed purchase price) as set forth in the Proposed Transfer Notice and such other terms as such Participating Investor or Investors and the Transferring Holder shall agree. In connection with such purchase by the Transferring Holder, such Participating Investor or Investors shall deliver to the Transferring Holder a stock certificate or certificates, properly endorsed for transfer, representing the shares being purchased by the Transferring Holder. Each such stock certificate delivered to the Transferring Holder will be transferred to the Prospective Transferee against payment therefor in consummation of the sale of the Transfer Stock pursuant to the terms and conditions specified in the Proposed Transfer Notice, and the Transferring Holder shall concurrently therewith remit or direct payment to each such Participating Investor the portion of the aggregate consideration to which each such Participating Investor is entitled by reason of its participation in such sale as provided in this paragraph (vi).

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(vii) Additional Compliance. If any Proposed Transfer is not consummated within one hundred eighty (180) days after receipt of the Proposed Transfer Notice, the Transferring Holder may not sell any Transfer Stock unless they first comply in full with each provision of this Section 5(c). The exercise or election not to exercise any right by any Party hereunder shall not adversely affect its right to participate in any other sales of Transfer Stock.

(viii) Violation of Tag-Along If any Transferring Holder purports to sell any Transfer Stock in contravention of the Tag-Along Right (a “Prohibited Transfer”), each Party who desires to exercise its Tag-Along Right may, in addition to such remedies as may be available by law, in equity or hereunder, require the Transferring Holder to purchase from such Party the type and number of Investor Shares or Other Shares that such Investor would have been entitled to sell to the Prospective Transferee had the Prohibited Transfer been effected in compliance with the terms of this Section 5(c). The sale will be made on the same terms and subject to the same conditions as would have applied had the Investor not made the Prohibited Transfer, except that the sale (including, without limitation, the delivery of the purchase price) must be made within ninety (90) days after the Party learns of the Prohibited Transfer, as opposed to the timeframe proscribed in paragraph (ii) above. Such Transferring Holder shall also reimburse each Party for any and all reasonable and documented out-of-pocket fees and expenses, including reasonable legal fees and expenses, incurred pursuant to the exercise or the attempted exercise of the Investor’s Tag-Along Right.

(d) Exempt Transfers. Notwithstanding the foregoing or anything to the contrary herein, the provisions of Sections 5(a) and (c) not apply: (i) in the case of a holder of Investor Shares or Other Shares that is an entity, upon a transfer by such holder to Affiliates, (ii) to a repurchase of Other Shares from an Other Stockholder by the Company at a price no greater than that originally paid by such Other Stockholder for such Other Shares and pursuant to an agreement containing vesting and/or repurchase provisions approved by the Board, (iii) in the case of Capital Royalty LP or its Affiliates, in connection with a transfer of all or a portion of its Investor Shares to a person in connection with the acquisition by such person, or by the Affiliates of such person, of all or a portion of the outstanding indebtedness of the Company to Affiliates of Capital Royalty LP under the terms of the Company’s loan facility with Capital Royalty LP, and in the case of any such person, any subsequent transfer of Investor Shares in connection with the sale of any portion of such acquired indebtedness, (iv) in the case of an Other Stockholder that is a natural person, upon a transfer of Transfer Stock by such Other Stockholder made for bona fide estate planning purposes, either during his or her lifetime or on death by will or intestacy, to his or her spouse, child (natural or adopted), or any other direct lineal descendant of such Other Stockholder (or his or her spouse) (all of the foregoing collectively referred to as “Family Members”), or any other relative approved by the Board, or any custodian or trustee of any trust, partnership or limited liability company for the benefit of, or the ownership interests of which are owned wholly by, such Other Stockholder or any such Family Members, (v) in the case of a holder of Investor Shares, upon a transfer by such holder to another Investor or an Affiliate of such other Investor or (vi) upon a Proposed Transfer approved by Holdings; provided that in the case of clauses (i), (iv), (v), and (vi), such shares of Transfer Stock shall at all times remain subject to the terms and restrictions set forth in this Agreement and such transferee shall, as a condition to such issuance, deliver a counterpart signature page to this Agreement as confirmation that such transferee shall be bound by all the terms and conditions of this Agreement as an Investor or Other Stockholder, as applicable, including the obligations with respect to Proposed Transfers of such Transfer Stock; and provided, further, in the case of any transfer pursuant to clause (iv) above, that such transfer is made pursuant to a transaction in which there is no consideration actually paid for such transfer.

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(e) Certain Legal Requirements. In the event that the consideration to be paid in exchange for Investor Shares or Other Shares in a Sale of the Company or a Proposed Transfer pursuant to Section 5(b) or Section 5(c) includes any securities, and the receipt thereof by an Investor or Other Stockholder would require under applicable law (i) the registration or qualification of such securities or of any Person as a broker or dealer or agent with respect to such securities where such registration or qualification is not otherwise required for the Sale of the Company or the Proposed Transfer or (ii) the provision to any Investor or Other Stockholder of any information regarding the Company, such securities or the issuer thereof, including by reason of the failure of one or more of such holders to be an “accredited investor” as such term is defined in Rule 501 of Regulation D of the Securities Act, such holder(s) shall not have the right to sell its Investor Shares or Other Shares in such proposed transaction. In such event, the Company or the Transferring Holder, as applicable, shall have the right, but not the obligation, to cause to be paid to such Investor or Other Stockholder in lieu thereof, against surrender of its Investor Shares or Other Shares which would have otherwise been sold in the proposed Sale of the Company or Proposed Transfer, an amount in cash equal to the fair market value of such shares as of the date such securities would have been issued in exchange for such shares.

6. Legend on Share Certificates. Each certificate representing any Investor Shares or Other Shares shall be endorsed by the Company with a legend reading substantially as follows:

“THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR HYPOTHECATED IN THE ABSENCE OF A REGISTRATION STATEMENT IN EFFECT WITH RESPECT TO THE SECURITIES UNDER SUCH ACT OR AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED OR UNLESS SOLD PURSUANT TO RULE 144 OF SUCH ACT.

THE SHARES EVIDENCED HEREBY ARE SUBJECT TO A STOCK PURCHASE AGREEMENT, VOTING AGREEMENT, AND INVESTORS’ RIGHTS AGREEMENT, AS EACH MAY BE AMENDED FROM TIME TO TIME (COPIES OF WHICH MAY BE OBTAINED FROM THE COMPANY WITHOUT COST UPON WRITTEN REQUEST), AND BY ACCEPTING ANY INTEREST IN SUCH SHARES, THE PERSON ACCEPTING SUCH INTEREST SHALL BE DEEMED TO AGREE TO AND SHALL BECOME BOUND BY ALL THE PROVISIONS OF SAID STOCK PURCHASE AGREEMENT, VOTING AGREEMENT, AND INVESTORS’ RIGHTS AGREEMENT, INCLUDING CERTAIN RESTRICTIONS ON TRANSFER AND OWNERSHIP SET FORTH THEREIN.”

7. Covenant of the Company. The Company will not, by any voluntary action, avoid or seek to avoid the observance or performance of any of the terms to be performed hereunder by the Company.

8. No Liability for Election of Recommended Directors. Neither the Company, the Investors, the Other Stockholders, nor any officer, director, stockholder, partner, employee or agent of any such Party, makes any representation or warranty as to the fitness or competence of the nominee of any Party hereunder to serve on the Board by virtue of such Party’s execution of this Agreement or by the act of such Party in voting for such nominee pursuant to this Agreement.

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9. Grant of Proxy. Upon the failure of any Investor or Other Stockholder to vote their Investor Shares or Other Shares, as applicable, in accordance with the terms of this Agreement, such Party hereby grants to the Chairman of the Board a proxy coupled with an interest in all Investor Shares and Other Shares owned by such Party, which proxy shall be irrevocable until this Agreement terminates pursuant to its terms or this Section 9 is amended to remove such grant of proxy in accordance with Section 16 hereof, to vote all such Investor Shares and Other Shares in the manner provided in this Agreement.

10. Specific Enforcement. It is agreed and understood that monetary damages would not adequately compensate an injured Party for the breach of this Agreement by any other Party, that this Agreement shall be specifically enforceable, and that any breach or threatened breach of this Agreement shall be the proper subject of a temporary or permanent injunction or restraining order. Further, each Party hereto waives any claim or defense that there is an adequate remedy at law for such breach or threatened breach.

11. Execution by the Company. The Company, by its execution in the space provided below, agrees that it will cause the certificates issued after the date hereof evidencing the shares of Investor Shares and Other Shares to bear the legend required by Section 6 hereof, and it shall supply, free of charge, a copy of this Agreement to any holder of a certificate evidencing shares of capital stock of the Company upon written request from such holder to the Company at its principal office, free of charge. The parties hereto do hereby agree that the failure to cause the certificates evidencing the shares of Investor Shares and Other Shares to bear the legend required by Section 6 hereof and/or failure of the Company to supply, free of charge, a copy of this Agreement, as provided under this Section 11, shall not affect the validity or enforcement of this Agreement.

12. Captions. The captions, headings and arrangements used in this Agreement are for convenience only and do not in any way limit or amplify the terms and provisions hereof.

13. Notices. All notices and other communications given or made pursuant hereto shall be in writing and shall be deemed effectively given or delivered: (i) upon personal delivery to the party to be notified, (ii) when sent by confirmed facsimile if sent during normal business hours of the recipient; if not, then on the next business day, (iii) five (5) days after having been sent by registered or certified mail, return receipt requested, postage prepaid, or (iv) one (1) day after deposit with a nationally recognized overnight courier, specifying next day delivery, with written verification of receipt. All communications shall be sent to the respective parties at the addresses set forth on the signature pages attached hereto (or at such other addresses as shall be specified by notice given in accordance with this Section 13).

14. Term. This Agreement shall terminate and be of no further force or effect upon (a) the consummation of the Company’s sale of its Common Stock or other securities pursuant to a registration statement under the Securities Act of 1933, as amended (other than a registration statement relating either to sale of securities to employees of the Company pursuant to its stock option, stock purchase or similar plan or a SEC Rule 145 transaction) or (b) the consummation of a Sale of the Company.

15. Manner of Voting. The voting of shares pursuant to this Agreement may be effected in person, by proxy, by written consent or in any other manner permitted by applicable law.

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16. Amendments and Waivers. Any term hereof may be amended and the observance of any term hereof may be waived (either generally or in a particular instance and either retroactively or prospectively) only with the written consent of (i) the Company and (ii) the Stockholders holding at least a majority of the then outstanding shares of Preferred Stock, voting together as a separate class on an as converted to Common Stock basis. Any amendment or waiver effected in accordance with this paragraph shall be binding upon the Company, each Investor and each Other Stockholder. Notwithstanding the foregoing, Section 3 shall not be amended or waived without the written consent of the particular Investors entitled to designate the directors in accordance with Section 3; provided, however, if any such Investor entitled to designate a director is subject to a Special Mandatory Conversion (as defined in the Restated Certificate), the consent of such particular Investor shall not be required to amend or waive Section 3.

17. Stock Splits, Stock Dividends, etc. In the event of any issuance of shares of the Company’s voting securities hereafter to any of the Parties hereto (including, without limitation, in connection with any stock split, stock dividend, recapitalization, reorganization or the like), such shares shall become subject to this Agreement and shall be endorsed with the legend set forth in Section 6.

18. Severability. Whenever possible, each provision of this Agreement shall be interpreted in such manner as to be effective and valid under applicable law, but if any provision of this Agreement shall be held to be prohibited by or invalid under applicable law, such provision shall be ineffective only to the extent of such prohibition or invalidity, without invalidating the remainder of such provision or the remaining provisions of this Agreement.

19. Additional Parties.

(a) In the event that, after the date of this Agreement, the Company enters into an agreement with any person to issue shares of capital stock (treating for this purpose all shares of Common Stock issuable upon exercise of or conversion of outstanding options, warrants or convertible securities, as if exercised and/or converted or exchanged) to someone that is not a party hereto, then the Company shall cause such person, as a condition to entering into such agreement, to become a party to this Agreement as an Other Stockholder, in the case of the issuance of Common Stock, and an Investor, in the case of Preferred Stock, by executing and delivering the Adoption Agreement attached to this Agreement as Exhibit A.

(b) Notwithstanding the terms of Section 16, Schedules A and B hereto may be amended by the Company from time to time without the consent of the other parties hereto to add information regarding Investors and Other Stockholders that become parties to this Agreement pursuant Section 19(a) above.

20. Binding Effect. In addition to any restriction on transfer that may be imposed by any other agreement by which any Party hereto may be bound, this Agreement shall be binding upon the Parties, their respective heirs, successors, transferees and assigns and to such additional individuals or entities that may become stockholders of the Company and that desire to become Parties hereto; provided that for any such transfer to be deemed effective, the transferee shall have executed and delivered an Adoption Agreement substantially in the form attached hereto as Exhibit A. Upon the execution and delivery of an Adoption Agreement by a transferee reasonably acceptable to the Company, such transferee shall be deemed to be a Party hereto as if such transferee’s signature appeared on the signature pages hereto. By its execution hereof or any Adoption Agreement, each of the Parties hereto appoints the Company as its attorney-in-fact for the purpose of executing any Adoption Agreement which may be required to be delivered hereunder.

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21. Governing Law. This Agreement shall be governed by and construed in accordance with the laws of the State of New York, without regard to conflicts of law principles thereof.

22. Entire Agreement. This Agreement is intended to be the sole agreement of the Parties as it relates to the subject matter hereof and supersede all other agreements of the Parties relating to the subject matter hereof. Upon the effectiveness of this Agreement, the Second Amended and Restated Voting Agreement, dated September 27, 2015, shall be deemed amended and restated and superseded and replaced in its entirety by this Agreement, and shall be of no further force or effect.

23. Counterparts. This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument.

24. Aggregation of Stock. All shares of capital stock of the Company held or acquired by affiliated entities (including affiliated venture capital funds) or persons shall be aggregated together for the purpose of determining the availability of any rights under this Agreement.

25. Certain Other Definitions. In addition the terms defined elsewhere in this Agreement, the following terms shall have the definitions set forth below for the purposes of this Agreement:

(a) “Affiliate” means any Person who, directly or indirectly, controls, is controlled by or is under common control with another Person, including, without limitation, any general partner, managing member, officer or director of such Person or any venture capital or private equity fund now or hereafter existing that is controlled by one or more general partners or managing members of, or shares the same management company with, such Person.

(b) “Person” means an individual, firm, corporation, partnership, association, limited liability company, trust or any other entity.

(c) “Proposed Transfer” means any assignment, sale, offer to sell, pledge, mortgage, hypothecation, encumbrance, disposition of or any other like transfer or encumbering of any Transfer Stock (or any interest therein) proposed by any Investor or Other Stockholder.

(d) “Proposed Transfer Notice” means written notice from the applicable Investor setting forth the terms and conditions of a Proposed Transfer.

(e) “Prospective Transferee” means any person to whom the applicable Investor proposes to make a Proposed Transfer.

(f) “Sale of the Company” means a transaction that qualifies as a “Liquidation Event” as defined in the Restated Certificate.

(g) “Tag-Along Right” means the right, but not the obligation, of a Party to participate in a Proposed Transfer to a Prospective Transferee on the terms and conditions specified in the Proposed Transfer Notice.

(h) “Transfer Stock” means the Investor Shares and/or Other Shares held by an Investor or Other Stockholder, as applicable.

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[Signature Pages Follow]

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IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED VOTING AGREEMENT

VALERITAS, INC.

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED VOTING AGREEMENT

VALERITAS, INC.

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED VOTING AGREEMENT

VALERITAS, INC.

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED VOTING AGREEMENT

VALERITAS, INC.

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED VOTING AGREEMENT

VALERITAS, INC.

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED VOTING AGREEMENT

VALERITAS, INC.

SCHEDULE A

INVESTORS

Valeritas Holdings, LLC

Capital Royalty Partners II, L.P.

Welsh, Carson, Anderson & Stowe XI, LP

WCAS Management Corporation

WCAS XI Co-Investors, LLC

Full Succeed International Limited

MPM BioVentures IV-QP, L.P.

MPM BioVentures IV GmbH & Co. Beteiligungs KG

MPM Asset Management Investors BV4 LLC

ONSET VI, L.P.

Pitango Venture Capital Fund V, L.P.

Pitango Venture Capital Principals Fund V, L.P.

Auda Capital IV Co-Investment GMBH & Co. KG

Auda Capital IV Co-Investment Fund L.P.

Auda Valeritas Segregated Portfolio

Abingworth BioVentures V LP

Advanced Technology Ventures VIII, L.P.

HLM Venture Partners II, L.P.

The Permanente Federation LLC – Series I

The Permanente Federation LLC – Series J

Kaiser Permanente Ventures, LLC – Series A

Kaiser Permanente Ventures, LLC – Series B

CHL Medical Partners III, LP

CHL Medical Partners III, LLC

CHL Medical Partners III, Side Fund, L.P.

Tullis Opportunity Fund, L.P.

Tullis Opportunity Fund II, L.P.

PED-VLRTS, LLC

Elizabeth Gordon

Evan Norton

Saint John’s University

Park Avenue (IOM) Limited

Tabaris Capital

SCHEDULE B

OTHER STOCKHOLDERS

None.

EXHIBIT A

ADOPTION AGREEMENT

This Adoption Agreement (“Adoption Agreement”) is executed by the undersigned (“Transferee”) pursuant to the terms of that certain Third Amended and Restated Voting Agreement dated as of January 29, 2016 (as the same may be amended, modified, restated or supplemented from time to time in accordance with its terms, the “Agreement”) by and among the Company and certain of its stockholders. Capitalized terms used but not defined herein shall have the respective meanings ascribed to such terms in the Agreement. By the execution of this Adoption Agreement, the Transferee hereby agrees as follows:

(a) Acknowledgment. Transferee acknowledges that Transferee is acquiring certain shares of the capital stock of the Company (the “Stock”), subject to the terms and conditions of the Agreement.

(b) Agreement. Transferee (i) agrees that the Stock acquired by Transferee shall be bound by and subject to the terms of the Agreement, (ii) shall be deemed an [Investor][Other Stockholder] for all purposes under the Agreement and (iii) hereby adopts the Agreement with the same force and effect as if Transferee were originally a Party thereto.

(c) Notice. Any notice required or permitted by the Agreement shall be given to Transferee at the address listed beside Transferee’s signature below.

EXECUTED AND DATED this             day of                     , 201    .

Accepted and Agreed: